microRNA-181a enhances cell proliferation in acute lymphoblastic leukemia by targeting EGR1

作者：Verduci Lorena; Azzalin Gianluca; Gioiosa Silvia; Carissimi Claudia; Laudadio Ilaria; Fulci Valerio^*; Macino Giuseppe

来源：Leukemia Research, 2015, 39(4): 479-485.

DOI：10.1016/j.leukres.2015.01.010

• Acute lymphoblastic leukemia (ALL)
• miR-181a
• EGR1
• onco-miRNA
• Cell proliferation
• Cell cycle

Acute lymphoblastic leukemia (ALL) is an aggressive cancer that occurs in both children and adults. Starting from an integrated analysis of miRNA/mRNA expression profiles in 20 ALL patients, we identify a negative correlation between miR-181a and EGR1. Coherently, miR-181a over-expression in Jurkat T-ALL cells decreases EGR1 expression, increasing cell proliferation and enhancing the cell-cycle progression from G(1) to S phase. We show that EGR1 is a new direct target of miR-181a. Our findings suggest that miR-181a behaves as an onco-miRNA in ALL by down-regulating EGR1.

• 出版日期2015-4