A convenient iodination of indoles and derivatives

作者：Hamri Salha; Rodriguez Jose; Basset Joan; Guillaumet Gerald; Dolors Pujol M

来源：Tetrahedron, 2012, 68(31): 6269-6275.

DOI：10.1016/j.tet.2012.05.053

• Iodoindoles
• Iodoazaindoles
• Electrophilic substitution
• Iodine reagents and iodination

We report a direct iodination of indole and derivative compounds with iodine monochloride (ICI) in the presence of Celite (R). This procedure has now been extended to the iodination of substituted indoles, azaindoles and pyrroles. The scope of this procedure is exemplified by the iodination of melatonin in 98% yield.

• 出版日期2012-8-5