A New Index for Acute Rejection After Renal Transplant: Notch Receptor-1

作者：Zheng, Kai; Sun, Xinghui; Wu, Weizhen; Yang, Shunliang; Cai, Jinquan; Tan, Jianming^*

来源：Experimental and Clinical Transplantation, 2012, 10(5): 433-438.

DOI：10.6002/ect.2011.0166

• Receptor
• Notch 1
• Acute rejection
• Kidney transplant
• Expression

Objectives: This study aimed at investigating the relation between expression of Notch receptor-1 (Notch 1) in peripheral blood mononuclear cells and acute rejection after renal transplant.
Materials and Methods: Ninety-seven patients receiving a renal transplant were randomly selected. Peripheral blood samples before transplant and days 1, 3, 5, 7, 10, 14, 21, and 30 after transplant were retrospectively observed. Expression of Notch 1 was detected by flow cytometry and real-time quantitative polymerase chain reaction.
Results: Expression of Notch 1 was correlated with acute rejection and long-term renal function after transplant (as detected by the level of serum creatinine 6 months after transplant). Expression of Notch 1 in peripheral blood mononuclear cells increased before serum creatinine increased. Expression of Notch 1 can reveal the immune state of recipients after transplant, and Notch 1 expression at early time points after transplant can predict long-term renal function.
Conclusions: Notch 1 can serve as an important index for acute rejection and long-term renal funcVon after transplant.

• 出版日期2012-10
• 单位中国人民解放军南京军区福州总医院