USE OF GRANULOCYTE COLONY STIMULATING FACTORS IN ONCOLOGICAL PATIENTS

作者：Alvarez Alejandro Gonzalez; Mari Asuncion Albert; Ma Angeles Lopez Montenegro Soria; Nicolas Victor Jimenez Torres

来源：Atencion Farmaceutica, 2010, 12(5): 273-+.

• GRANULOCYTE COLONY STIMULATING FACTOR
• ABSOLUTE NEUTROPHIL COUNT
• COST-EFFECTIVENESS
• PEGFILGRASTIM
• FILGRASTIM

Objective: To compare the hematological response after the administration of filgrastim and pegfilgrastim to patients with solid tumors who receive myelo-suppressive chemotherapy in primary prophylaxis.
Method: Observational, longitudinal and prospective study from January to June of 2009. Main variable: absolute neutrophil count (ANC) since the first chemotherapy cycle for both treatment groups. Secondary variable: rate of patients with neutrophil values greater than the maximum limit of 8 x 10(9)/L (ANC > 8).
Results: 22 patients were included in the study In the fourth chemotherapy cycle, we obtained for filgrastim an average ANC of 3.52 x 10(9)/L, and for pegfilgrastim of 6.91 x 10(9)/L (p = 0.078). No significant differences existed in ANC > 8 x 10(9)/L between both treatment groups (p > 0.05).
Conclusions: We observe a cumulative effect in ANC for pegfilgrastim, due to which patients with ANC > 8 could be candidates for improving their pharmacotherapy by means of using non-pegylated factors, with the purpose of achieving more cost-effective treatments.

• 出版日期2010-10