Neurochemical early diagnostics and clinical neuro-proteomics of dementia disorders

作者：Wiltfang J^*; Bibl M; Maier M; Klafki H; Esselmann H; Kornhuber J; Lewczuk P

来源：Nervenheilkunde, 2007, 26(10): 853-+.

This article summarises the current achievements in neurochemical dementia diagnostics (NDD) with special emphasis on applications which have already been introduced into routine diagnostics or which are expected to be introduced shortly. Based on independent multi center studies with several thousands of patients the following neurochemical dementia markers have been validated in cerebrospinal fluid (CSF-NDD): beta-amyloid peptides, total tau and hyperphosphorylated tau proteins (phospho-tau). These studies clearly show that CSF-NDD is of high clinical relevance for the improved early and differential diagnosis of dementias and that it also does offer a diagnostic tool for the predictive diagnosis of incipient Alzheimer's dementia.

• 出版日期2007