Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation

作者：Feijs Karla L H; Forst Alexandra H; Verheugd Patricia; Luescher Bernhard

来源：Nature Reviews Molecular Cell Biology, 2013, 14(7): 443-451.

DOI：10.1038/nrm3601

ADP-ribosylation of proteins was first described in the early 1960%26apos;s, and today the function and regulation of poly(ADP-ribosyl)ation (PARylation) is partially understood. By contrast, little is known about intracellular mono(ADP-ribosyl) ation (MARylation) by ADP-ribosyl transferase (ART) enzymes, such as ARTD10. Recent findings indicate that MARylation regulates signalling and transcription by modifying key components in these processes. Emerging evidence also suggests that specific macrodomain-containing proteins, including ARTD8, macroD1, macroD2 and C6orf130, which are distinct from those affecting PARylation, interact with MARylation on target proteins to %26apos;read%26apos; and %26apos;erase%26apos; this modification. Thus, studying macrodomain-containing proteins is key to understanding the function and regulation of MARylation.

• 出版日期2013-7