Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: Results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids

作者：Stephenson James A^*; Al Taan Omer; Arshad Ali; West Annette L; Calder Philip C; Morgan Bruno; Metcalfe Matthew S; Dennison Ashley R

来源：Prostaglandins, Leukotrienes and Essential Fatty Acids, 2013, 88(6): 405-410.

DOI：10.1016/j.plefa.2013.04.002

• n-3 PUFA
• Fish oil
• Cancer
• Liver tissue composition
• Tumour composition

Introduction: Mediators derived from the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid oxidation have been shown to have tumour promoting effects in experimental models, while n-3 PUFAs are thought to be protective. Here we report fatty acid concentrations in hepatic colorectal metastases compared to liver tissue without tumour in humans. %26lt;br%26gt;Methods: Twenty patients with colorectal liver metastasis were randomized to receive a 72 h infusion of parenteral nutrition with or without n-3 PUFAs. Histological samples from liver metastases and liver tissue without tumour were obtained from 15 patients at the time of their subsequent liver resection (mean 8 days (range 4-12) post-infusion) and the fatty acid composition determined by gas chromatography. %26lt;br%26gt;Results: There were no significant differences in fatty acid composition between the two intervention groups. When data from all patients were combined, liver tissue without tumour had a higher content of both n-3 and n-6 PUFAs and a lower content of oleic acid and total n-9 fatty acids compared with tumour tissue (p %26lt; 0.0001, 0.0002, %26lt; 0.0001 and %26lt; 0.0001, respectively). The n-6/n-3 PUFA ratio was found to be higher in tumour tissue than tissue without tumour (p %26lt; 0.0001). %26lt;br%26gt;Conclusions: Hepatic colorectal adenocarcinoma metastases have a higher content of n-9 fatty acids and a lower content of n-6 and n-3 PUFAs than liver tissue without tumour.

• 出版日期2013-6