Association of Serotype-Specific Antibody Concentrations and Functional Antibody Titers with Subsequent Pneumococcal Carriage in Toddlers Immunized with a 9-Valent Pneumococcal Conjugate Vaccine

作者：Simell Birgit^*; Nurkka Anu; Lahdenkari Mika; Givon Lavi Noga; Kayhty Helena; Dagan Ron; Jokinen Jukka

来源：Clinical and Vaccine Immunology, 2012, 19(1): 96-99.

DOI：10.1128/CVI.05369-11

Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.

• 出版日期2012-1