Antipsychotic-induced tardive movement disorders: A focused review

作者：Denizot Helene; Rolland Benjamin; Nijhout Caroline; Charpeaud Thomas; Chereau Isabelle; Llorca Pierre Michel

来源：ANNALES MEDICO-PSYCHOLOGIQUES, 2017, 175(5): 474-479.

DOI：10.1016/j.amp.2017.03.006

• Adverse drug reactions
• Dopamine
• Epidemiology
• Prevention
• Psychotropic
• Semiology

Antipsychotic-induced tardive movement disorders (ATMDs) constitute a set of late-onset involuntary movements, resulting from the blocking of dopamine receptors. ATMDs are generally underscreened by health professionals, though they may also occur with new generation antipsychotics. ATMDs encompass several specific clinical types: tardive dyskinesia, tardive dystonia, tardive akathisia, tardive tremor, tardive myoclonus, tardive stereotypy, tardive tourettism, tardive parkinsonism, and withdrawal emergent syndrome. The prevalence rates of ATMDs are high, and the outcome may be variable. The most evidenced risk factor for ATMDs is age. Primary and secondary prevention rely on systematically assessing the clinical risk factors before prescribing an antipsychotic medication, and regularly undertaking a neurological examination. Managing ATMDs requires decreasing, stopping, or changing the antipsychotic treatment. Specific reversing drugs, such as reserpine, can be used, though the levels of evidence of these drugs are low. Surgery can be considered in the case of severe and resistant ATMDs.

• 出版日期2017-6