A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride center dot diethyl etherate under mild conditions

作者：Minh Thanh La; Kim Hee Kwon^*

来源：Tetrahedron, 2018, 74(27): 3748-3754.

DOI：10.1016/j.tet.2018.05.050

• Esterification
• Tert-butyl ester
• Carboxylic acid
• Boron trifluoride center dot diethyl etherate
• Protecting groups

A practical direct preparation of tert-butyl esters from 2-tert-butoxypyridine has been developed. This system features the use of boron trifluoride center dot diethyl etherate in toluene solvent to rapidly achieve the reaction at room temperature. Using this reaction protocol, a variety of ten-butyl esters were synthesized from several different carboxylic acids at high yields. This practical procedure provides a promising and effective approach to the protection of carboxylic acids with a tert-butyl group.

• 出版日期2018-7-5