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摘要
An efficient microwave-assisted synthesis of (+/-)-mandelic acid-d(5) was developed. The racemic mixture was resolved by diastereomeric salt formation using 1-phenylethylamine enantiomers as resolving agents. At each step, the resolution process was checked by determining mandelic acid-d(5) enantiomer ee values directly on fractional crystalized diastereomeric salts by chiral capillary electrophoresis analysis. Highly enriched (-)- and (+)-mandelic acid-d(5) (95% and 90% ee, resp.) were obtained and their absolute configurations-R and S, respectively-were determined by correlation of the (-)-mandelic acid-d(5) circular dichroism spectrum to the (R)-mandelic acid one.
- 出版日期2013
