Methylene blue-loaded gold nanobipyramids @SiO2 enhanced singlet oxygen generation for phototherapy of cancer cells

作者：Lv, Junliang; Wu, Gongqing; He, Yang; Zhang, Lijuan; Yi, Yunhong^*

来源：Optical Materials Express, 2017, 7(2): 409-414.

DOI：10.1364/OME.7.000409

• PHOTODYNAMIC THERAPY
• NANOPARTICLES

Plasmonic nanoparticles hold great potential in photodynamic therapy (PDT). Herein, a nanoplatform of methylene blue (MB) loaded gold nanobipyramids@SiO2 (GBPs@SiO2-MB) was designed to optimize the generation rate of singlet oxygen (O-1(2)), which was based on the plasmonic effect. The surface plasmon resonance (SPR) of GBPs was finely overlapped with the excitation absorption of MB, a wildly applied organic PDT drug prone to enzymatic degradation. This mesoporous silica coating nanoplatform protects MB molecules against degradation, and this overlap greatly enhances the O-1(2) yield of MB by the SPR electron from the GBPs. The GBPs@SiO2-MB nanoparticles exhibit a synergistic effect of PDT and photothermal therapies (PTT) of cancer cells under laser irradiation. This study provides a alternative strategy to improve the classic MB treatment for phototherapy application.

• 出版日期2017-2-1
• 单位广东药科大学