An Intervention to Support HIV Preexposure Prophylaxis Adherence in HIV-Serodiscordant Couples in Uganda

作者：Psaros Christina^*; Haberer Jessica E; Katabira Elly; Ronald Allan; Tumwesigye Elioda; Campbell James D; Wangisi Jonathan; Mugwanya Kenneth; Kintu Alex; Enyakoit Michael; Thomas Katherine K; Donnell Deborah; Krows Meighan; Kidoguchi Lara; Ware Norma; Baeten Jared M; Celum Connie; Bang**erg David R; Safren Steve A

来源：JAIDS: Journal of Acquired Immune Deficiency Syndromes , 2014, 66(5): 522-529.

DOI：10.1097/QAI.0000000000000212

• preexposure prophylaxis
• adherence
• intervention
• serodiscordant couples
• HIV prevention

Background: Daily preexposure prophylaxis (PrEP) is an effective HIV prevention strategy, but adherence is required for maximum benefit. To date, there are no empirically supported PrEP adherence interventions. This article describes the process of developing a PrEP adherence intervention and presents results on its impact on adherence. %26lt;br%26gt;Methods: The Partners PrEP Study was a placebo-controlled efficacy trial of daily oral tenofovir and emtricitabine/tenofovir PrEP among uninfected members of HIV-serodiscordant couples. An ancillary adherence study was conducted at 3 study sites in Uganda. Participants with %26lt;80% adherence as measured by unannounced pill count received an additional adherence counseling intervention based on Lifesteps, an evidence-based HIV treatment adherence intervention, based on principles of cognitive-behavioral theory. %26lt;br%26gt;Findings: Of the 1147 HIV-seronegative participants enrolled in the ancillary adherence study, 168 (14.6%) triggered the adherence intervention. Of participants triggering the intervention, 62% were men; median age was 32.5 years. The median number of adherence counseling sessions was 10. Mean adherence during the month before the intervention was 75.7% and increased significantly to 84.1% in the month after the first intervention session (P %26lt; 0.001). The most frequently endorsed adherence barriers at session 1 were travel and forgetting. %26lt;br%26gt;Interpretation: A PrEP adherence intervention was feasible in a clinical trial of PrEP in Uganda and PrEP adherence increased after the intervention. Future research should identify PrEP users with low adherence for enhanced adherence counseling and determine optimal implementation strategies for interventions to maximize PrEP effectiveness.

• 出版日期2014-8-15