A phase II trial of accelerated hypofractionated three-dimensional conformal radiation therapy in locally advanced non-small cell lung cancer

作者：Zhu, Zheng-Fei; Fan, Min; Wu, Kai-Liang; Zhao, Kuai-Le; Yang, Huan-Jun; Chen, Gui-Yuan; Jiang, Guo-Liang; Wang, Li-Juan; Zhao, Sen; Fu, Xiao-Long^*

来源：Radiotherapy and Oncology, 2011, 98(3): 304-308.

DOI：10.1016/j.radonc.2011.01.022

• Non-small cell lung cancer
• Accelerated radiotherapy
• Hypofractionation

Purpose: The aim of this study is to evaluate the safety and efficacy of accelerated hypofractionated radiotherapy (HypoRT) combined with sequential chemotherapy in locally advanced non-small cell lung cancer (NSCLC). @@@ Materials and methods: A total of 34 patients with stage III NSCLC were enrolled. All patients received accelerated HypoRT (initially 50 Gy/20 fractions, then a fraction dose of 3 Gy) using three-dimensional conformal radiation therapy (3D-CRT), omitting elective nodal irradiation (EN!), to a total dose of 6568 Gy. All patients received two cycles of induction chemotherapy; 1-2 cycles of consolidation chemotherapy were given to 31 patients. The primary outcome measure was a profile of radiation toxicity. The secondary endpoints included overall survival (OS), progression-free survival (PFS), locoregional PFS (LR-PFS) and the pattern of initial failure. @@@ Results: Radiation toxicity was minimal. The median and 3-year OS, PFS were 19.0 months, 32.1%; 10.0 months, 29.8%, respectively. The 1-, 2-, and 3-year LR-PFS were 69.6%, 60.9% and 60.9%, respectively. No patient experienced isolated elective nodal failure as the first site of failure. @@@ Conclusion: This study suggests that accelerated HypoRT using 3D-CRT omitting ENI can be used in combination with sequential chemotherapy in locally advanced NSCLC.

• 出版日期2011-3
• 单位复旦大学