Antiproliferative metabolites from the endophytic fungus Penicillium sp FJ-1 isolated from a mangrove Avicennia marina

作者：Zheng, Chao; Chen, Yang; Jiang, Li-Li; Shi, Xiao-Ming^*

来源：Phytochemistry Letters, 2014, 10: 272-275.

DOI：10.1016/j.phytol.2014.10.011

• Avicennia marina
• Endophytic fungus
• Penicillium sp FJ-1
• Anti-tumoral activities
• Nude mice

Two new compounds, named as 4-(2',3'-dihydroxy-3'-methyl-butanoxy)-phenethanol (1), and 15-hydroxy-6 alpha, 12-epoxy-7 beta, 10 alpha H, 11 beta H-spiroax-4-ene-12-one (2), were isolated from the endophytic fungus Penicillium sp. FJ-1 of Avicennia marina. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compounds 1 and 2 exhibited antiproliferative activities, and compound 2 significantly inhibited the tumor growth of human xenograft osteosarcoma in nude mice.

• 出版日期2014-12
• 单位临沂市人民医院