Antitussive effect of bakumondoto a fixed kampo medicine (six herbal components) for treatment of post-infectious prolonged cough: Controlled clinical pilot study with 19 patients

作者：Irifune Kazunori^*; Hamada Hironobu; Ito Ryoji; Katayama Hitoshi; Watanabe Akira; Kato Aki; Miyoshi Seigo; Hamaguchi Naohiko; Toyozawa Ryo; Hamaguchi Sachiko; Abe Masahiro; Nishimura Kazutaka; Higaki Jitsuo

来源：Phytomedicine, 2011, 18(8-9): 630-633.

DOI：10.1016/j.phymed.2011.02.017

• PIPC
• Bakumondoto
• Medicine
• Fixed herbal kampo medicine
• Cough

Bakumondoto (TJ-29) is a traditional herbal medicine that has been used in Japan for the treatment of bronchitis, bronchial asthma, and cough. This study investigated the effect of TJ-29 for the treatment of post-infectious prolonged cough. We performed a multicenter randomized controlled trial treating patients without (group A. n=11) or with TJ-29 (group B. n=8) for a total of 2 weeks using a beta 2 stimulant as the basal agent. Efficacy and safety were compared by a cough diary, VAS and sleeping questionnaire. At 4 and 5days after treatment, the cough score of group B showed significant improvement compared with group A, demonstrating an early antitussive effect. At the assessment 2 weeks after treatment start, both groups showed similar levels of improvement in the cough score. No significant difference was observed in the VAS and the sleeping questionnaire items. In conclusion, oral TJ-29 administration could be useful and safe for the treatment of post-infectious prolonged cough.

• 出版日期2011-6-15