A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity

作者：Ruiz Victoria E; Battaglia Thomas; Kurtz Zachary D; Bijnens Luc; Ou Amy; Engstrand Isak; Zheng Xuhui; Iizumi Tadasu; Mullins Briana J; Mueller Christian L; Cadwell Ken; Bonneau Richard; Perez Perez Guillermo I; Blaser Martin J^*

来源：Nature Communications, 2017, 8(1): 518.

DOI：10.1038/s41467-017-00531-6

Broad-spectrum antibiotics are frequently prescribed to children. Early childhood represents a dynamic period for the intestinal microbial ecosystem, which is readily shaped by environmental cues; antibiotic-induced disruption of this sensitive community may have long-lasting host consequences. Here we demonstrate that a single pulsed macrolide antibiotic treatment (PAT) course early in life is sufficient to lead to durable alterations to the murine intestinal microbiota, ileal gene expression, specific intestinal T-cell populations, and secretory IgA expression. A PAT-perturbed microbial community is necessary for host effects and sufficient to transfer delayed secretory IgA expression. Additionally, early-life antibiotic exposure has lasting and transferable effects on microbial community network topology. Our results indicate that a single early-life macrolide course can alter the microbiota and modulate host immune phenotypes that persist long after exposure has ceased.

• 出版日期2017-9-11