科研之友
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摘要
Increasing evidence has highlighted the impact of inflammation in colorectal cancer (CRC), but the effects of the inflammatory process on CRC remain largely unknown. Neurokinin A (NKA) presents in the tumor microenvironment and could induce neurogenic inflammation by intracellular signaling through NK2R. However, the precise significance of NKA and its receptor NK2R in CRC need to be fully defined. We performed Immunohistochemistry staining on tissue microarrays (TMA) containing 90 pairs of CRC and adjacent normal tissues to evaluate the clinical significance of NKA or NK2R in CRC, and the potential correlation between NKA and NK2R in CRC development was also explored. The expressions of NKA and NK2R were overexpressed in CRC (P<0.001). High expression of NKA in CRC was significantly associated with lymph node metastasis (P=0.008) and TNM stage (P=0.021). Meanwhile, high expression of NK2R in CRC was significantly related to tumor diameter (P=0.025), pathology grading (P=0.032) and lymph node metastasis (P=0.046). A high correlation between NKA and NK2R expression was also observed (r=0.229, P=0.030). Survival analysis showed that CRC patients with high expression of NKA or NK2R have a poorer survival than those with low NKA or NK2R expression (Log rank test, P<0.05). Multivariate analysis using Cox regression model showed that survival was independently correlated with age, distant metastasis, TNM stage and NK2R expression (P<0.05). In conclusion, high expression of NKA-NK2R may play pro-inflammatory role in CRC carcinogenesis and progression, which may also be used as predictors for prognosis of CRC.
- 出版日期2016
- 单位浙江大学; 浙江省人民医院; 绍兴市人民医院
