Differential behavioural responses to venlafaxine exposure route, warming and acidification in juvenile fish (Argyrosomus regius)

作者：Maulvault Ana Luisa; Santos Lucia H M L M; Paula Jose Ricardo; Camacho Carolina; Pissarra Vasco; Fogaca Fabiola; Barbosa Vera; Alves Ricardo; Ferreira Pedro Pousao; Barcelo Damia; Rodriguez Mozaz Sara; Marques Antonio; Diniz Mario; Rosa Rui

来源：Science of the Total Environment, 2018, 634: 1136-1147.

DOI：10.1016/j.scitotenv.2018.04.015

• Fish behaviour
• Antidepressants
• Venlafaxine
• Ocean warming
• Ocean acidification

Antidepressants, such as venlafaxine (VFX), which are considered emerging environmental pollutants, are increasingly more present in the marine environment, and recent evidence suggest that they might have adverse effects on fish behaviour. Furthermore, altered environmental conditions associated to climate change (e.g. warming and acidification) can also have a determinant role on fish behaviour, fitness and survival. Yet, the underlying interactions between these environmental stressors (pharmaceuticals exposure and climate change) are still far from being fully understood. The aim of this study was to assess behavioural responses (in juvenile meagre (Argyrosomus regius) exposed to VFX via water ([ VFX] similar to 20 mu g L-1) and via dietary sources ([ VFX] similar to 160 mu g kg(-1) dry weight), as well as to increased temperature (Delta T degrees C - +5 degrees C) and high CO2 levels (Delta pCO(2) similar to 1000 mu atm; equivalent to Delta pH = -0.4 units). Overall, VFX bioaccumulation in fish plasma was enhanced under the combination of warming and acidification. VFX triggered fish exploration, whereas fish activity and shoal cohesion were reduced. Acidification alone decreased fish exploration and shoal cohesion, and reversed fish preference to turn leftwards compared to control conditions. Such alterations were further enhanced by VFX exposure. The combination of warming and acidification also reduced shoal cohesion and loss of lateralization, regardless of VFX exposure. The distinct behaviour observed when VFX contamination, acidification and warming acted alone or in combination highlighted the need to consider the likely interactive effects of seawater warming and acidification in future research regarding the toxicological aspects of chemical contaminants.

• 出版日期2018-9-1