Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population

作者：Chen, Shiqing; Huang, Xiaoye; Yu, Tao; Li, Xin; Cao, Yanfei; Li, Xingwang; Xu, Fei; Yang, Fengping; Jesse, Forrest Fabian; Xu, Mingqing; Li, Weidong; He, Lin^*; He, Guang

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2015, 56: 97-100.

DOI：10.1016/j.pnpbp.2014.08.008

• Association
• Bipolar disorder
• Case-control study
• Chinese Han population
• TPH2

Objective: Bipolar disorder (BPD) is a serious and common mental disorder with high heritability. The serotonergic system is known to be implicated in the etiology of the disorder. Tryptophan hydroxylase isoform-2 (TPH2), which controls the synthesis of serotonin in the brain, has been suggested as a candidate gene for BDP. The aim of this study was to examine the association between the polymorphisms in TPH2 and BPD.
Methods: We conducted a case-control study by genotyping six SNPs (rs10784941, rs1386494, rs2171363, rs4760816, rs1386486, and rs1872824) in 506 bipolar patients and 507 controls of Chinese Han origin.
Results: rs10784941 was not in the Hardy-Weinberg equilibrium and therefore excluded from further analysis. rs1386486 and rs1872824 showed statistically significant differences between cases and controls in genotype frequencies (rs1386486: p = 0.043351; rs1872824: p = 0.016563), but no association in allele frequencies. Strong LD was found among rs1386494, rs2171363 and rs4760816, but no positive association with BPD was found for haplotypes.
Conclusion: Our results indicate that in the Han Chinese population TPH2 may be a potential susceptibility gene for bipolar disorder. Further studies are needed to validate this association.

• 出版日期2015-1-2
• 单位中国科学院; 上海交通大学; 复旦大学; 中国科学院上海生命科学研究院