A new suprasterol by photochemical reaction of 1 alpha,25-dihydroxy-9-methylene-19-norvitamin D3

作者:Kulesza Urszula; Plum Lori A; DeLuca Hector F; Mourino Antonio*; Sicinski Rafal R*
来源:Organic and Biomolecular Chemistry, 2016, 14(5): 1646-1652.
DOI:10.1039/c5ob01896j

摘要

The UV-induced photochemical reaction of 1 alpha,25-dihydroxy-9-methylene-19-norvitamin D-3 has been investigated. The pentacyclic structure of the isolated product has been unequivocally established by X-ray crystallographic analysis. The possible reaction paths of the examined photochemical transformation are discussed. Biological in vivo and in vitro tests proved that the photoproduct is devoid of calcemic activity.

  • 出版日期2016

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