Phytochemicals: Countering risk factors and pathological responses associated with ischaemia reperfusion injury

作者：Gillespie Scarlett; Gavins Felicity N E^*

来源：Pharmacology & Therapeutics, 2013, 138(1): 38-45.

DOI：10.1016/j.pharmthera.2012.12.005

• Phytochemical
• Heart
• Brain
• Ischaemia-reperfusion
• Sulforaphane

Plant derived non-nutritive molecules, known as phytochemicals, have been investigated for their ability to provide protection against inflammation. Emerging studies of several vasculopathies (e.g. atherosclerosis, hypertension) provide novel data to support these anti-inflammatory effects and offer evidence for involvement of host pathways. Fundamental mechanisms of action are common amongst these compounds, and furthermore, the administration of these phytochemicals activates host defence pathways innately present to protect cells from oxidative stress. This review will elucidate the real benefit of therapeutic intervention with these phytochemicals for vasculopathies, and associated ischaemia reperfusion injury in both the heart and brain.

• 出版日期2013-4