Extracorporeal shock wave lithotripsy is safe and effective for pediatric patients with chronic pancreatitis

作者：Wang, Dan; Bi, Ya-Wei; Ji, Jun-Tao; Xin, Lei; Pan, Jun; Liao, Zhuan; Du, Ting-Ting; Lin, Jin-Huan; Zhang, Di; Zeng, Xiang-Peng; Ye, Bo; Zou, Wen-Bin; Chen, Hui; Xie, Ting; Li, Bai-Rong; Zheng, Zhao-Hong; Li, Zhao-Shen^*; Hu, Liang-Hao^*

来源：Endoscopy, 2017, 49(5): 447-455.

DOI：10.1055/s-0043-104527

• CHRONIC CALCIFIC PANCREATITIS
• RISK-FACTORS
• EUROPEAN-SOCIETY
• CHILDREN
• MANAGEMENT
• STONES
• RECOMMENDATIONS
• ENDOTHERAPY
• GUIDELINE
• DIAGNOSIS

Background and aims Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is recommended as the first-line treatment for pancreatic stones. However, how well P-ESWL performs in pediatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for pediatric patients with chronic pancreatitis. @@@ Methods This prospective observational study was conducted in patients with painful chronic pancreatitis who underwent P-ESWL. Patients aged under 18 years were included in the pediatric group; patients aged over 18 years who underwent P-ESWL in the same period were assigned to the control group. For investigation of long-term follow-up, the pediatric group were matched with patients from the control group in a 1: 1 ratio. The primary outcomes were P-ESWL complications and pain relief. The secondary outcomes included: stone clearance, physical and mental health, quality of life score, and growth and developmental state. @@@ Results From March 2011 to March 2015, P-ESWL was performed in 1135 patients (72 in the pediatric group, 1063 in the control group). No significant differences were observed in the occurrence of P-ESWL complications between the two groups (11.1% vs. 12.8%; P = 0.68). Among the 67 pediatric patients (93.1%) who underwent follow-up for 3.0 years (range 1.3-5.2), complete pain relief was achieved in 52 patients (52/67; 77.6%); this value was not significantly different from that of the matched controls (55/69; 79.7%; P = 0.94). @@@ Conclusions P-ESWL is safe and effective for pediatric patients with chronic pancreatitis. It can promote significant pain relief and stone clearance, and can benefit growth and development.

• 出版日期2017-5
• 单位中国人民解放军第二军医大学; 东南大学; 中国人民解放军空军总医院