Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line

作者：Seira Naofumi; Yanagisawa Naoki; Suganami Akiko; Honda Takuya; Wasai Makiko; Regan John W; Fukushimai Keijo; Yamaguchi Naoto; Tamura Yutaka; Arai Takayoshi; Murayama Toshihiko; Fujino Hiromichi^*

来源：Biological & Pharmaceutical Bulletin, 2017, 40(10): 1806-1812.

DOI：10.1248/bpb.b17-00458

• indole compound
• MW-03
• prostaglandin E-2
• 15-hydroxyprostaglandin dehydrogenase
• peroxisome proliferator-activated receptor-gamma
• colon cancer

Increases in the expression of prostaglandin E-2 (PGE(2)) are widely known to be involved in aberrant growth in the early stage of colon cancer development. We herein demonstrated that the novel indole compound MW-03 reduced PGE(2)-induced cAMP formation by catalization to an inactive metabolite by inducing 15-hydroxyprostaglandin dehydrogenase through the activation of peroxisome proliferator-activated receptor-gamma. MW-03 also inhibited colon cancer cell growth by arresting the cell cycle at the S phase. Although the target of MW-03 for cell cycle inhibition has not yet been identified, these dual anti-cancer effects of MW-03 itself and/or its leading compound(s) on colon cancer cells may reduce colon cancer development and, thus, have potential as a novel treatment for the early stage of this disease.

• 出版日期2017-10