Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease

作者：Ebihara Kosuke; Ishida Yasushi^*; Takeda Ryuichiro; Abe Hiroshi; Matsuo Hisae; Kawai Keiichi; Magata Yasuhiro; Nishimori Toshikazu

来源：Neuroscience Letters, 2011, 496(2): 90-94.

DOI：10.1016/j.neulet.2011.03.087

• 6-Hydroxydopamine
• L-DOPA
• Abnormal involuntary movement
• Immediate-early gene protein
• Immunohistochemistry

A study was carried out to examine the effects of acute and chronic L-DOPA treatment on the distribution of the immediate-early gene (IEG) proteins (FosB, c-Fos, and zif268) in forebrain regions in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease. During a course of chronic L-DOPA treatment (15 mg/day, 15 days), rats with a 6-OHDA lesion developed abnormal involuntary movements. Compared with the rats in the acute L-DOPA treatment group, those in the chronic treatment group had significantly more FosB-immunopositive cells in the anterior cingulate (Cg) and the dorsolateral caudate-putamen ipsilateral to the lesion and significantly fewer c-Fos-immunopositive cells in the Cg, the nucleus accumbens shell, and the basolateral nucleus of amygdala ipsilateral to the lesion. No significant difference was observed in the number of Zif268-immunopositive cells between the acute and chronic L-DOPA groups. In summary, differential expression of three IEG proteins was observed in the forebrain regions during a course of chronic L-DOPA treatment of 6-OHDA-treated hemiparkinsonian rats.

• 出版日期2011-6-1
• 单位河北医科大学