Asymmetric Synthesis of Tertiary Benzylic Alcohols

作者：Antczak Monika I; Cai Feng; Ready Joseph M^*

来源：Organic Letters, 2011, 13(2): 184-187.

DOI：10.1021/ol102567h

Vinyl, aryl, and alkynyl organometallics add to ketones containing a stereogenic sulfoxide. Tertiary alcohols are generated in diastereomerically and enantiomerically pure form. Reductive lithiation converts the sulfoxide into a variety of useful functional groups.

• 出版日期2011-1-21