A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth

作者：Kim Ki Hyun; Beemelmanns Christine; Clardy Jon; Cao Shugeng^*

来源：Bioorganic & Medicinal Chemistry Letters, 2015, 25(14): 2834-2836.

DOI：10.1016/j.bmcl.2015.04.094

• Pogostemon cablin
• Lamiaceae
• Octaketide
• Antibacterial activity
• Cytotoxicity

A new octaketide, named cytosporone V (1), and two other known phenylethanoid glycosides (2-3), were isolated from the aerial parts of Pogostemon cablin (Blanco) Benth. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR and HR-MS. Compounds 1-3 displayed weak antibacterial activity against two gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus. All isolates were also evaluated for their antiproliferative activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15). Compounds 2 and 3 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values ranging from 2.73 to 9.52 mu M.

• 出版日期2015-7-15