NMR Kinetics of the S(N)2 Reaction between BuBr and I-: An Introductory Organic Chemistry Laboratory Exercise

作者：Mobley T Andrew^*

来源：Journal of Chemical Education, 2015, 92(3): 534-537.

DOI：10.1021/ed500371h

• Second-Year Undergraduate
• Hands-On Learning/Manipulatives
• Laboratory Instruction
• Organic Chemistry
• Physical Chemistry
• Kinetics
• Rate Law
• Mechanisms of Reactions
• Nucleophilic Substitution
• NMR Spectroscopy

A simple organic chemistry experiment is described that investigates the kinetics of the reaction between 1-bromobutane (BuBr) and iodide (I-) as followed by observing the disappearance of BuBr and the appearance of 1-iodobutane (BuI) using H-1 NMR spectroscopy. In small groups of three to four, students acquire data to examine the concentration-dependence of both the organic substrate and the nudeophile under pseudo-first-order and second-order conditions. After data processing, students analyze three data sets (one second-order experiment, and two first-order experiments with different concentrations of iodide) using an electronic spreadsheet. Students discuss the experimentally determined rate law, comparing it to that predicted for this S(N)2 reaction.

• 出版日期2015-3