Retinal optical coherence tomography at 1 mu m with dynamic focus control and axial motion tracking

作者：Cua Michelle; Lee Sujin; Miao Dongkai; Ju Myeong Jin; Mackenzie Paul J; Jian Yifan; Sarunic Marinko V

来源：Journal of Biomedical Optics, 2016, 21(2): 026007.

DOI：10.1117/1.JBO.21.2.026007

• high-resolution optical coherence tomography
• focus-stacking
• variable-focus lens
• en face optical coherence tomography
• graphics processing unit acceleration

High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample arm optics. Retinal layer tracking and selection was performed using a graphics processing unit accelerated processing platform for focus optimization, providing real-time layer-specific en face visualization. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the retina and optic nerve head, from which we extracted clinically relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

• 出版日期2016-2