Decreased GLT-1 and increased SOD1 and HO-1 expression in astrocytes contribute to lumbar spinal cord vulnerability of SOD1-G93A transgenic mice

作者：Guo, Yansu; Duan, Weisong; Li, Zhongyao; Huang, Jing; Yin, Yunxia; Zhang, Kunxi; Wang, Qian; Zhang, Zhifang; Li, Chunyan^*

来源：FEBS LETTERS, 2010, 584(8): 1615-1622.

DOI：10.1016/j.febslet.2010.03.025

• ALS
• Astrocyte
• SOD1
• Heme oxygenase-1
• Transgenic mice

The SOD1-G93A transgenic mouse is a widely used ALS model, but the death of lower motor neurons is the hallmark. Here, we show that the SOD1-G93A transgene and HO-1 are preferentially over-expressed in the lumbar spinal cord, particularly in the activated astrocytes of the transgenic mice. We also show down-regulation of GLT-1 in spite of the proliferating astrocytes. However, GLT-1, SOD1-G93A transgene and HO-1 expression were not obviously changed in the motor cortex. Our data link spinal cord vulnerability to relatively decreased expression of GLT-1, and high expression of the transgene and HO-1 in astrocytes in SOD1-G93A transgenic mice.

• 出版日期2010-4-16
• 单位河北医科大学