A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells

作者：Liu, Lin; Chen, Baoan^*; Qin, Shukui; Li, Suyi; He, Xiangming; Qiu, Shaomin; Zhao, Wei; Zhao, Hong

来源：Biochemical and Biophysical Research Communications, 2010, 392(2): 190-195.

DOI：10.1016/j.bbrc.2010.01.011

• HDAC inhibitor
• Apoptosis
• Colon cancer cells
• Chidamide

Many studies have demonstrated that histone deacetylase (HDAC) inhibitors induce various tumor cells to undergo apoptosis, and such inhibitors have been used in different clinical trials against different human cancers. In this study, we designed and synthesized a novel HDAC inhibitor, Chidamide. We showed that Chidamide was able to increase the acetylation levels of histone H3 and to inhibit the PI3K/Akt and MAPK/Ras signaling pathways, which resulted in arresting colon cancer cells at the G1 phase of the cell cycle and promoting apoptosis. As a result, the proliferation of colon cancer cells was suppressed in vitro. Our data support the potential application of Chidamide as an anticancer agent in treating colon cancer. Future Studies are needed to demonstrate its in vivo efficacy.

• 出版日期2010-2-5
• 单位东南大学; 中国人民解放军第八一医院