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摘要
Background: We conducted this systematic review and meta-analysis to evaluate the association between essential hypertension (EH) and bone mineral density (BMD). Results: 17 articles were included in our meta-analysis, with a total of 39,491 patients. Of these, 13,375 were patients with EH and 26,116 were patients without EH. Meta-analysis results showed that EH can reduce the BMD of the lumbar spine (95% CI: -0.08 similar to 0.01, P=0.006), femoral neck (95% CI: -0.09 similar to-0.02, p=0.001), ward's triangle (95% CI: -0.45 similar to-0.25, p=0.000), femoral intertrochanteric (95% CI: -0.90 similar to 0.64, p = 0.000), calcaneus (95% CI: -0.31 similar to-0.18, p = 0.000) and distal forearm (95% CI: -0.09 similar to-0.03, p = 0.000), but EH cannot reduce the BMD of the femur rotor (95% CI: -0.07 similar to 0.24, p = 0.273). Subgroup analysis showed that EH can reduce the BMD of the lumbar spine (95% CI: -0.11 similar to-0.03, p = 0.000) and femoral neck (95% CI: -0.11 similar to-0.07, p = 0.000) in Asian populations. In non-Asian populations, EH can reduce the BMD of the femoral neck (95% CI: 0.04 similar to 0.19, p = 0.002), but cannot reduce the BMD of the lumbar spine (95% CI: -0.04 similar to 0.11, p = 0.346). Materials and Methods: We conducted a systematic review of the published literature on the association of EH and BMD by searching the Cochrane Library, PubMed, EMBASE, CBM, CNKI and VIP databases inception to October 2016. Stata 11.0 software was used for data analysis. Conclusions: Our meta-analysis suggests that EH can reduce the BMD of the human body, and for different parts of the bone, the degree of reduction is different. In addition, for different regions and populations, the reduction level of BMD is inconsistent.
- 出版日期2017-9-15
- 单位广西医科大学
