科研之友
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摘要
A homodinuclear Co-2/aminophenol sulfonamide complex has been developed for the asymmetric Michael reaction of -ketoesters with nitroolefins. This procedure is capable of tolerating a wide range of substrates and excellent results (up to 99% yield, >99:1 dr and 98% ee) can also be obtained. Moreover, the reaction could be carried out on a 50 mmol scale without any decrease in the enantioselectivity and reactivity. On the basis of the results of mechanistic studies, we proposed that the Co-2/2a complex would be the active species and a possible catalytic cycle was described.
- 出版日期2018-5-28
- 单位重庆医科大学
