Nanoparticles of metal-organic cages designed to encapsulate platinum-based anticancer agents

作者：Yue Zhizhou; Wang Han; Bowers David J; Gao Min; Stilgenbauer Morgan; Nielsen Frederick; Shelley Jacob T; Zheng Yao Rong^*

来源：Dalton Transactions, 2018, 47(3): 670-674.

DOI：10.1039/c7dt03537c

We present a novel design to use metal-organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(IV) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host-guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer.

• 出版日期2018-1-21