Ascorbate enhances iron uptake into intestinal cells through formation of a FeCl3-ascorbate complex

作者：Thumser Alfred E^*; Rashed Aswir Abd; Sharp Paul A; Lodge John K

来源：Food Chemistry, 2010, 123(2): 281-285.

DOI：10.1016/j.foodchem.2010.04.031

• Enterocyte iron uptake
• Ascorbate
• Ferric iron

It has been well documented that ascorbate enhances iron uptake, with a proposed mechanism based on reduction to the more absorbable ferrous form. We have performed a study on the effects of ascorbate on ferric iron uptake in the human epithelial Caco-2 cell-line. Ascorbate increased uptake in a concentration-dependent manner with a significant difference between iron uptake and reduction. Uptake kinetics are characteristic of a non-essential activator and the formation of an Fe3+-ascorbate complex. This investigation provides evidence that ascorbate enhances the apical uptake of ferric iron into Caco-2 cells through the formation of a Fe3+-ascorbate complex.

• 出版日期2010-11-15
• 单位河北医科大学