An efficient one-pot synthesis of tri-substituted thiophenes via a multicomponent reaction in water

作者:Moghaddam Firouz Matloubi*; Bardajee Ghasem Rezanejade; Dolabi Maliheh
来源:Journal of Sulfur Chemistry, 2010, 31(5): 387-393.
DOI:10.1080/17415993.2010.496129

摘要

An efficient one-pot synthesis of functionalized trisubstituted thiophenes via the reaction of 3-morpholino-3-thioxopropanenitrile, cyclohexyl isocyanide and -haloketones is reported. This method provides a straightforward route to a variety of highly substituted thiophenes not easily accessible by conventional methods.

  • 出版日期2010