ANTIMICROBIAL AND ANTIHYPERLIPIDEMIC ACTIVITIES OF ISOLATED QUERCETIN FROM ANABAENA AEQUALIS

作者：Abdel Raouf Neveen; Ibraheem Ibraheem B M^*; Abdel Tawab Sanaa; Naser Yamna A G

来源：Journal of Phycology, 2011, 47(4): 955-962.

DOI：10.1111/j.1529-8817.2011.01020.x

• Anabaena aequalis
• antihyperlipidemic agent
• antimicrobial activity
• cyanobacteria
• quercetin

This study aimed to isolate quercetin (for the first time) from Anabaena aequalis Borge, which inhabits soil surface of Wadi El-Alaqui Protectorate located in Aswan city, Egypt. The isolated compound showed significant antibacterial activity against the gram-positive bacteria Sarcina maxima and Micrococcus kristinae, the gram-negative bacterium Klebsiella pneumoniae, as well as against the filamentous fungus Aspergillus flavus. The isolated compound was identified as quercetin using the structure elucidation based on UV, electrospray ionization mass spectrometry (ESIMS), (1)H and (13)C NMR, proton-proton correlation spectroscopy ((1)H-(1)H COSY), distortion-less enhancement by polarization transfer (DEPT), heteronuclear single quantum coherence (HSQC), and heteronuclear multiple bond correlations spectrum (HMBC). Medium lethal dose (LD(50)) of the isolated compound and its side effects against hyperlipidemia induced by ethanol intake in albino rats were carried out. No deaths were reported in rats within 72 h, which suggests that the isolated compound plays a beneficial role as an antihyperlipidemic agent in the treatment of alcohol-induced hepatic tissue damage, which can be described as one of the therapeutic values.

• 出版日期2011-8