MR-GUIDED PULSE OXIMETRY IMAGING OF BREAST IN VIVO

作者：Li Zhiqiu; Jiang Shudong; Krishnaswamy Venkataramanan; Davis Scott C; Srinivasan Subhadra; Paulsen Keith D; Pogue Brian W^*

来源：Journal of Innovative Optical Health Sciences, 2011, 4(2): 199-208.

DOI：10.1142/S1793545811001459

• High frame-rate
• fast imaging
• MR-guided
• near-infrared tomography
• breast hemodynamics

A near-infrared (NIR) tomography system with spectrally-encoded sources in two wavelength bands was built to quantify the temporal oxyhemoglobin and deoxyhemoglobin contrast in breast tissue at a 20 Hz bandwidth. The system was integrated into a 3T magnetic resonance (MR) imaging system through a customized breast coil interface for simultaneous optical and MRI acquisition. In this configuration, the MR images provide breast tissue structural information for NIR spectroscopy of adipose and fibro-glandular tissue in breast. Spectral characterization performance of the NIR system was verified through dynamic phantom experiments. Normal human subjects were imaged with finger pulse oximeter (PO) plethysmogram synchronized to the NIR system to provide a frequency-locked reference. Both the raw data from the NIR system and the recovered absorption coefficients of the breast at two wavelengths showed the same frequency of about 1.3 Hz as the PO output. The frequency lock-in approach provided a practical platform for MR-localized recovery of small pulsatile variations of oxyhemoglobin and deoxyhemoglobin in the breast, which are related to the heartbeat and vascular resistance of the tissue.

• 出版日期2011-4