Facile catalyst-free pseudo five-component domino reactions in the expedient synthesis of 5-aroyl-1,3-diarylhexahydropyrimidines

作者：Muthusaravanan Sivasubramanian; Perumal Subbu^*; Almansour Abdulrahman I

来源：Tetrahedron Letters, 2012, 53(9): 1144-1148.

DOI：10.1016/j.tetlet.2011.12.097

• Domino reaction
• (E)-3-(Dimethylamino)-1-arylprop-2-en-1-one
• Formaldehyde
• Aniline
• 5-Aroyl-1,3-diarylhexahydropyrimidines

The pseudo five-component domino reactions of (E)-3-(dimethylamino)-1-arylprop-2-en-1-one, formaldehyde and aniline afford 5-aroyl-1,3-diarylhexahydropyrimidines in good yields under catalyst-free conditions. This transformation involving 4 C-N and 1 C-C bond formations in a one pot operation presumably proceeds via Michael addition-elimination-Mannich type reaction-condensative annulation-reduction sequence.

• 出版日期2012-2-29