Antinociceptive action of GLYX-13: an N-methyl-D-aspartate receptor glycine site partial agonist

作者：Wood Paul L; Mahmood Siddique A; Moskal Joseph R^*

来源：NeuroReport, 2008, 19(10): 1059-1061.

DOI：10.1097/WNR.0b013e32830435c9

• chronic nerve constriction model
• formalin model
• gabapentin
• GLYX-13
• neuropathic pain
• partial glycine agonist

Inhibition of N-methyl-D-aspartate (NMDA)-mediated neurotransmission has been demonstrated to provide antinociceptive actions in a number of animal models of tonic and neuropathic pain. However, both competitive and noncompetitive NMDA receptor antagonists are ataxic at analgesic doses. Partial agonists and antagonists of the NMDA-associated glycine site have demonstrated antinociceptive actions at doses that are not ataxic. In this study, we present data showing that GLYX-13, an NMDA receptor, glycinesite, partial agonist, also is antinociceptive in the rat formalin model of tonic pain and in the rat constriction nerve injury model of neuropathic pain at doses not inducing ataxia.

• 出版日期2008-7-2
• 单位西北大学