Non-atheromatous arterial stenoses in atypical haemolytic uraemic syndrome associated with complement dysregulation

作者：Loirat Chantal^*; Macher Marie Alice; Elmaleh Berges Monique; Kwon Theresa; Deschenes Georges; Goodship Timothy H J; Majoie Charles; Davin Jean Claude; Blanc Raphael; Savatovsky Julien; Moret Jacques; Fremeaux Bacchi Veronique

来源：Nephrology Dialysis Transplantation, 2010, 25(10): 3421-3425.

DOI：10.1093/ndt/gfq319

• angioplasty
• arterial stenosis
• atypical haemolytic uraemic syndrome
• complement factor B
• complement factor H

Results. Stenoses of both carotid arteries, left subclavian and vertebral arteries, several intracranial, right humeral, several coronary, and all pulmonary arteries were demonstrated. At the age of 13 years, left subclavian and right cervical carotid arteries were occluded. Right carotid recanalization induced intracranial dissection and death. The child had a Lys350Asp factor B mutation.
Conclusion. Arterial steno-occlusive lesions appear as potential complications of dysregulated complement activation in aHUS. Endovascular treatment should be considered cautiously in this setting.

• 出版日期2010-10