Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling

作者：Budreck Elaine C; Kwon Oh Bin; Jung Jung Hoon; Baudouin Stephane; Thommen Albert; Kim Hye Sun; Fukazawa Yugo; Harada Harumi; Tabuchi Katsuhiko; Shigemoto Ryuichi; Scheiffele Peter^*; Kim Joung Hun

来源：Proceedings of the National Academy of Sciences, 2013, 110(2): 725-730.

DOI：10.1073/pnas.1214718110

• synapse
• neurotranmitter receptor
• neurexin

Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorly understood. The cell adhesion molecule neuroligin-1 (NL1) modifies NMDAR-dependent synaptic transmission and synaptic plasticity, but it is unclear whether NL1 controls synaptic accumulation or function of the receptors. Here, we provide evidence that NL1 regulates the abundance of NMDARs at postsynaptic sites. This function relies on extracellular, NL1 isoform-specific sequences that facilitate biochemical interactions between NL1 and the NMDAR GluN1 subunit. Our work uncovers NL1 isoform-specific cis-interactions with ionotropic glutamate receptors as a key mechanism for controlling synaptic properties.

• 出版日期2013-1-8