Anaerobic photocleavage of supercoiled DNA by a ruthenium(II) substituted fluorinated porphyrin

作者:McCrate Anna; Carlone Melissa; Nielsen Mark; Swavey Shawn*
来源:Inorganic Chemistry Communications, 2010, 13(4): 537-539.
DOI:10.1016/j.inoche.2010.01.031

摘要

Two ruthenium substituted porphyrins differing only by the substitution of a mesopentafluorophenyl group show drastically different DNA photocleavage results. The incorporation of the pentafluorophenyl group provides greater photodynamic efficiency and in addition is capable of causing DNA cleavage in the absence of oxygen.

  • 出版日期2010-4