A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure

作者：Margolis Kara Gross^*

来源：Journal of Chemical Neuroanatomy, 2017, 83: 36-40.

DOI：10.1016/j.jchemneu.2017.02.001

• Serotonin
• Serotonin reuptake transporter
• Autism spectrum disorders
• Antidepressants
• Selective serotonin reuptake inhibitors
• Brain-gut axis
• 5-HT4 receptor

Many disease conditions considered CNS-predominant harbor significant intestinal comorbidities. Serotonin (5-HT) and the serotonin reuptake transporter (SERT) have increasingly been shown to play important roles in both brain and intestinal development and long-term function. 5-HT and SERT may thus modulate critical functions in the development and perpetuation of brain-gut axis disease. We discuss the potential roles of 5-HT and SERT in the brain and intestinal manifestations of autism spectrum disorders and developmental antidepressant exposure. The potential therapeutic value of 5-HT4 modulation in the subsequent treatment of these conditions is also addressed.