A General Catalyst for Site-Selective C(sp(3))-H Bond Amination of Activated Secondary over Tertiary Alkyl C(sp(3))-H Bonds

作者：Scamp Ryan J; Jirak James G; Dolan Nicholas S; Guzei Ilia A; Schomaker Jennifer M^*

来源：Organic Letters, 2016, 18(12): 3014-3017.

DOI：10.1021/acs.orglett.6b01392

The discovery of transition metal complexes capable of promoting general, catalyst-controlled and selective carbon-hydrogen (C-H) bond amination of activated secondary C-H bonds over tertiary alkyl C(sp(3)-H bonds is challenging, as substrate control often dominates when reactive nitrene intermediates are involved. In this letter, we report the design of a new silver complex, [(Py5Me2)AgOTf](2), that displays general and good-to-excellent selectivity for nitrene insertion into propargylic, benzylic, and allylic C-H bonds over tertiary alkyl C(sp(3))-H bonds.

• 出版日期2016-6-17