Lysosomal enzymes may cross the blood-brain-barrier by pinocytosis: Implications for Enzyme Replacement Therapy

作者：Baldo Guilherme^*; Giugliani Roberto; Matte Ursula

来源：Medical Hypotheses, 2014, 82(4): 478-480.

DOI：10.1016/j.mehy.2014.01.029

Here we hypothesized that the water-soluble lysosomal enzymes may cross the blood-brain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis. We also highlight studies that show that, at higher serum concentrations, a fraction of these proteins can reach the brain after intravenous injection, and we suggest some experiments to study this hypothesis. Finally we discuss the implications of this for treatments such as enzyme replacement of lysosomal storage disorders.

• 出版日期2014-4