Microbiological N-deoxygenation and C-oxygenation of pioglitazone-N-oxide in a single fermentation

作者：Johnson RA^*; Marshall VP; Li GP; Sih JC; Cialdella JI; Liggett WF; Nidy EG

来源：Journal of Antibiotics, 1996, 49(8): 788-793.

Oxygenation of pioglitazone-N'-oxide by a microorganism isolated from soil was accompanied by N-deoxygenation to produce the pioglitazone metabolites 5-[4-[2-[5-(1-hydroxyethyl)-2-pyridyl]ethoxy]benzyl]-2,4-thiazolidinedione and 5-[4-[2-(5-acetyl-2-pyridyl)ethoxy] benzyl]-2,4-thiazolidinedione. The oxygenating/deoxygenating organism has been characterized as Streptomyces hygroscopicus strain 02179 (UC 11099). The culture has been deposited with Agricultural Research Service, USDA, with accession number NRRL 18975.

• 出版日期1996-8