A revision of the organ radiation doses from 2-fluoro-2-deoxy-D-glucose with reference to tumour presence

作者：Staaf Johan; Jacobsson Hans; Sanchez Crespo Alejandro^*

来源：Radiation Protection Dosimetry, 2012, 151(1): 43-50.

DOI：10.1093/rpd/ncr471

Absorbed radiation doses to major human organs after intravenous bolus administration of 2-[F-18]fluoro-2-deoxy-d-glucose (FDG) were reviewed. Absorbed doses were calculated using the medical internal radiation dose (MIRD) formalism from experimental activitytime curves. Thirty patients (22 with macroscopic lung tumour and 8 without observable disease) were investigated using a state-of-the-art combined positron emission tomography/computer tomography system (Siemens Biograph 64). Each patient underwent a series of 10 consecutive whole-body PET scans during the first 60-min post-FDG administration. Differences were observed between organ radiation doses in this work and those reported in International Commission for Radiation Protection 106 (21 in effective dose). The presence of tumour did not affect the FDG biodistribution. Large inter-individual variations in organ-absorbed doses were observed. This in combination with the lack of a model for bladder voiding suitable for all patients suggests the need for a more precise estimate of normal-organ radiation doses. This will be beneficial in optimising FDG administration in clinical routine.

• 出版日期2012-8