Albumin levels and cause-specific mortality in community-dwelling older adults

作者：Wu Chen Yi; Hu Hsiao Yun; Huang Nicole; Chou Yi Chang; Li Chung Pin; Chou Yiing Jenq

来源：Preventive Medicine, 2018, 112: 145-151.

DOI：10.1016/j.ypmed.2018.04.015

• Albumin
• Mortality
• Community-dwelling
• Older adults

To investigate the association between serum albumin levels and cause-specific mortality among community-dwelling older adults. This cohort study was based on data obtained from the government-sponsored Annual Geriatric Health Examination Program for the older adults in Taipei City between 2006 and 2010. The study sample consisted of 77,531 community-dwelling Taipei citizens (>= 65 years old). Mortality was determined by matching the participants' medical records with national death files. Serum albumin levels were categorized into < 3.6, 3.6-3.7, 3.8-3.9, 4.0-4.1, 4.2-4.3, and >= 4.4 g/dL. Cox proportional hazards regression models were used to evaluate the association between albumin levels and cause-specific mortality. Spline regression was used to calculate the risk of mortality associated with albumin levels, modeled as continuous variables. Community-dwelling older adults had a mean albumin level of 4.3 g/dL, which significantly reduced by age. Compared to albumin levels >= 4.4 g/dL, mildly low albumin levels (4.2-4.3 g/dL) were associated with an increased mortality risk (hazard ratio [HR]: 1.16, 95% confidence interval [CI]: 1.05-1.28 for all-cause mortality), and albumin levels < 4.2 g/dL were associated with significantly higher rates of all-cause, cancer, cardiovascular, and respiratory mortalities. In the spline regression, the curve of mortality risk was relatively flat at an albumin level >= 4.4 g/dL, and the mortality risk gradually increased as the albumin level declined. Albumin levels >= 4.4 g/dL were associated with better survival among community-dwelling older adults, and mortality risk increased as the albumin level decreased.

• 出版日期2018-7