A Comparison of the Transcutaneous Kinetics of Six Commercial Formulations of Hydrocortisone

作者：Ahlstrom L A^*; Cross S E; Mills P C

来源：Australian Veterinary Practitioner, 2011, 41(1): 24-+.

The aim of this study was to compare the penetration of hydrocortisone through canine skin in vitro, when applied from six, commercially available, veterinary or human medical creams containing 0.5% hydrocortisone (HC) or hydrocortisone acetate (HCA). Full thickness skin was mounted in Franz-type diffusion cells and randomly divided for use between treatment groups of different HC or HCA formulations. The amount of HC penetrating the skin in the 30 hours following application of a cream was quantified using HPLC analyses. The rate of transderrnal penetration of HC from one cream was 1.7, 1.9, 13.1 and 20.6 times greater than from four others, respectively. This study has shown that the rate of penetration through dog skin can vary greatly from different formulations of the same

• 出版日期2011-3